At least four teams booked their places in the FA quarter-final following Tuesday’s ties.
Manchester City midfielder, Phil Foden, scored twice as the Premier League champions thrashed Bristol City 3-0.
Kevin De Bruyne rounded off the scoring with a sublime finish from 25 yards.
Second-tier Blackburn Rovers eliminated Leicester City winning 2-1.
Tyrhys Dolan and Sammie Szmodics scored, before a Kelechi Iheanacho reply.
Fulham reached the sixth round for the first time in 13 years thanks to goals by Joao Palhinha and Manor Solomon, which earned them a 2-0 win over Leeds United.
Brighton and Hove Albion needed Evan Ferguson’s first-half goal to claim a 1-0 win over second-tier Stoke City.
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